成年Fontan患者的维生素D缺乏和二次性甲状腺功能障碍
Friederike Löffler1, Justus Christian Garlichs1, Sabrina Uehlein1
1Medizinische Hochschule Hannover, Department of Cardiology and Angiology, Hannover, Germany.
International journal of cardiology. Congenital heart disease
|December 23, 2024
概括
成年Fontan患者通常患有维生素D缺乏症和二次性副甲状腺功能障碍症 (sHPT). 副甲状腺激素 (PTH) 水平与心力衰竭的严重程度相关,这表明PTH在这个人群中是潜在的生物标志物.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 成年Fontan患者中维生素D缺乏和二次性甲状腺功能障碍症 (sHPT) 的患病率尚不清楚.
- 维生素D和副甲状腺激素 (PTH) 在评估Fontan患者心力衰竭中的作用尚不清楚.
研究的目的:
- 为了确定维生素D缺乏和sHPT在成人Fontan患者的患病率.
- 分析维生素D,PTH水平和Fontan患者的临床结果之间的关联.
主要方法:
- 在35名成年Fontan患者中比较维生素D缺乏和sHPT患病率,与14名成年先天性心脏病患者 (ACHD) 相比.
- 分析了实验室测量,患者特征和临床事件之间的相关性.
主要成果:
- 维生素D缺乏在两组中都非常普遍 (76.5%的Fontan和71.4%的ACHD).
- sHPT仅在Fontan患者中发现 (31.4%).
- PTH水平与心力衰竭严重程度 (NYHA类,心室功能,NT-proBNP) 和炎症标志物 (GDF-15) 相相关.
- 芬顿的sHPT患者因心力衰竭和心房节律失常而住院的比例更高.
结论:
- 这项研究是首次报告成人Fontan患者中维生素D缺乏和sHPT的高患病率.
- PTH与心力衰竭的严重程度有很强的相关性,这表明它有可能在Fontan患者中成为一种有价值的生物标志物.
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