多发性硬化症中的慢性活性病变:分类,术语和临床意义
Assunta Dal-Bianco1,2, Jiwon Oh3, Pascal Sati4
1Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.
Therapeutic advances in neurological disorders
|December 23, 2024
概括
多发性硬化症 (MS) 中燃烧的神经炎症涉及慢性活性病变 (CALs). 新的成像技术可以检测到这些病变,如偏磁边缘病变 (PRLs),有助于MS诊断和预后.
科学领域:
- 神经免疫学 神经免疫学
- 神经成像是一种神经成像.
- 多发性硬化症的病理生理学
背景情况:
- 中枢神经系统 (CNS) 中持续的慢性炎症,称为燃烧的神经炎症,导致多发性硬化症 (MS) 的渐进性残疾.
- 燃烧的神经炎症在MS临床谱中普遍存在,并且通常对当前的疾病修饰疗法具有抗性.
- 慢性活跃病变 (CALs) 是燃烧的神经炎症的关键表现,特别是在白质中.
研究的目的:
- 审查当前对慢性活性病变 (CAL) 生物学和体内成像技术的理解.
- 讨论CALs在多发性硬化症 (MS) 自然史中的临床相关性.
- 概述CALs的体内生物标志物的开发和验证的考虑因素.
主要方法:
- 审查新兴的体内神经成像技术和后处理方法,以可视化慢性活性病变 (CALs).
- 作为CALs的成像相关物,对偏磁边缘病变 (PRLs) 和缓慢扩张的病变的特征.
- 对纵向研究的分析,将体内检测到的CAL与疾病进展联系起来.
主要成果:
- 包括PRL在内的CALs的体内成像方法正在迅速发展.
- 偏磁边缘病变 (PRL) 对多发性硬化高度特异,并已纳入诊断标准.
- 纵向研究将体内检测到的CAL与更具侵略性的疾病过程和预后潜力联系在一起.
结论:
- 慢性活跃病变 (CALs) 是MS中燃烧的神经炎症的关键指标,影响疾病进展.
- 在体内成像生物标志物,如PRLs,显示出对MS诊断和预测患者结果的希望.
- 进一步验证,标准化和自动化对于CAL生物标志物的临床实用性在MS护理和治疗评估中至关重要.
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