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对Nirmatrelvir (Paxlovid) 在SARS-CoV-2 Mpro中耐药性的研究

Rasha M Yaghi1, Dennis C Wylie2, Collin L Andrews1

  • 1Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, The United States of America.

ACS bio & med chem Au
|December 23, 2024
PubMed
概括

在SARS-CoV-2主要蛋白酶 (Mpro) 变体中,耐尼马特里尔维尔耐药性发展缓慢. 鉴定的突变显示活性降低,常见的患者突变赋予了最小的抗药性,表明nirmatrelvirvir.

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