循环中介素-18水平与成人发病史蒂尔病之间的关联:元分析
1Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Journal of rheumatic diseases
|December 23, 2024
概括
在成人发病的斯蒂尔病 (AOSD) 患者中,循环中介素-18 (IL-18) 水平显著升高. 较高的IL-18也与AOSD中增加的费里和C反应蛋白相关.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 成人发病的斯蒂尔病 (AOSD) 是一种罕见的全身炎症疾病.
- 介素-18 (IL-18) 是一种促炎性细胞因子,涉及各种自身免疫和自身炎症性疾病.
研究的目的:
- 调查循环中介素-18 (IL-18) 水平与成人发病的斯蒂尔病 (AOSD) 之间的关联.
- 通过元分析来综合现有证据.
主要方法:
- 在 MEDLINE,Embase 和 Web of Science 进行了系统的文献搜索.
- 进行了一项元分析,比较AOSD患者与对照患者的血清/血IL-18水平.
- 根据种族,样本大小和数据类型进行了子组分析.
主要成果:
- 分析包括13项研究 (562名AOSD患者,790名对照).
- 与对照组相比,在AOSD患者中观察到显著增加的IL-18水平 (SMD=1.899,p<0.001).
- 在亚洲和欧洲人群,各种样本大小和数据类型中,IL-18的升高水平是一致的. 在活跃的AOSD中,自由IL-18的含量更高. 在IL-18和费里丁 (r=0.542) 和C反应蛋白之间发现了正相关性.
结论:
- 在患有成人发病斯蒂尔病的患者中,循环IL-18水平显著增加.
- 在AOSD中,IL-18水平与关键炎症标记物 - - 费里丁和C反应蛋白 - - 有着积极的相关性.
- IL-18可能作为AOSD活动和炎症的潜在生物标志物.
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