自闭症儿童的耐药性易怒性和相关因素
Hasan C Aykutlu1, Leyla Bozatlı1, Işık Görker1
1Child and Adolescent Psychiatry Department, Trakya University Faculty of Medicine, Edirne, Turkey.
International journal of developmental disabilities
|December 23, 2024
概括
相当数量的自闭症儿童经历了耐药性易怒性 (DRI),这是标准抗精神病治疗无效的情况. 高龄和共同出现的疾病,如焦虑和睡眠问题是自闭症中DRI的关键风险因素.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科医生精神病学 儿科精神病学
- 临床心理学 临床心理学
背景情况:
- 自闭症儿童经常表现出易怒,包括侵略和发,影响日常生活.
- 目前的抗精神病治疗对于这些儿童的很大一部分是无效的.
- 自闭症中耐药性刺激性 (DRI) 需要进一步调查.
研究的目的:
- 在一大批自闭症儿童的临床样本中确定药物耐药性刺激 (DRI) 的频率.
- 在这个人群中识别与DRI相关的风险因素.
主要方法:
- 对1279名自闭症儿童 (2-18岁) 的医疗记录进行了回顾性分析.
- 收集的数据包括社会经济和临床特征,同时出现的精神疾病和身体状况.
- 统计分析以确定DRI的重大风险因素.
主要成果:
- 8.2%的样本符合耐药性易怒性 (DRI) 的标准.
- 55%的样本使用抗精神病药物来控制易怒.
- DRI的危险因素包括年龄较大,严重的自闭症支持需求,语言障碍,焦虑,睡眠困难和胃肠道/牙问题.
结论:
- 在临床环境中,显著比例的自闭症儿童表现出耐药性易怒性 (DRI).
- 确定的风险因素 (身体,精神,环境) 表明DRI的异质原因.
- 进一步的研究对于开发自闭症中DRI的有效治疗和预防策略至关重要.
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