父亲对性二态的发育编程的影响
Shefa' M Aljabali1,2, Shruta Pai1,2, Raffaele Teperino1,2
1Institute of Experimental Genetics, Helmholtz Munich GmbH, German Research Center for Environmental Health, Neuherberg, Germany.
Frontiers in cell and developmental biology
|December 23, 2024
概括
怀孕前的父亲因素显著影响后代的性变态. 这些非遗传因素对男性和女性的发育有不同的影响,这凸显了对哺乳动物的性别特定研究的需要.
科学领域:
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
- 遗传学 遗传学 是一个
背景情况:
- 性二态性包括两性之间的解剖学,生理学,行为和发育差异.
- 这些差异受孕前和早期发育因素的影响,影响表型和疾病风险.
- 超过一半的小鼠定量特征表现出基于性别的变化,由荷尔蒙,性染色体和印记基因驱动.
研究的目的:
- 审查父性非遗传因素对哺乳动物性二态化的影响.
- 综合关于父亲健康如何影响子女表现型的研究,以性别特定的方式.
- 探索间接的父亲对后代发展的影响.
主要方法:
- 文学综合当前关于父亲对性二重形的影响的研究.
- 检查表观遗传机制,包括DNA甲基化和父性印记基因.
- 精子RNA和精子血贡献的分析.
- 通过母亲的行为,子宫和胎盘变化来探索间接的父亲影响.
主要成果:
- 父亲非遗传因素可以诱导后代表型的性别特异性变化.
- 机制包括表观遗传修饰 (DNA甲基化,印记),精子RNA和精子血.
- 母亲环境和胎盘功能间接介导的间接父亲影响也会对性别特异性结果产生影响.
- 这些因素在关键发育时期调节性二态.
结论:
- 怀孕前的父亲健康和环境因素在塑造性二态化方面发挥着至关重要的作用.
- 了解这些非遗传影响对于全面了解哺乳动物发育和疾病至关重要.
- 未来的哺乳动物研究必须包含性别特定的文档,以充分阐明这些复杂的相互作用.
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