在接受结肠镜检查的老年患者中比较雷米马佐拉姆与普罗波的认知恢复:一项随机对照试验
Shuying Lin1, Ying Wei2, Yifen Zhuo3
1Department of Anesthesiology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, People's Republic of China.
雷米马佐拉姆在接受结肠镜检查的老年患者中提供了与普罗波相似的认知恢复. 这种新型药物提供了更高的满意度和更好的安全性,使其成为程序镇静的潜在替代品.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 老年医学 老年医学
背景情况:
- 雷米马佐拉姆是一种新型的超短效二胺,具有治疗过程镇静的潜力.
- 接受结肠镜检查等手术的老年患者代表了一个易受镇静治疗的群体.
- 普罗波是一种常用的程序镇静剂,但可能有相关的不良事件.
研究的目的:
- 在接受结肠镜检查的老年患者中,比较雷米马佐拉姆和普罗波之间的认知恢复.
- 为了评估患者的满意度和remimazolam与propofol的安全性概况.
- 为了确定雷米马佐拉姆作为替代普罗波福的疗效,用于手术镇静.
主要方法:
- 一项前性,随机,双盲,受控试验,涉及228名接受门诊结肠镜检查的老年患者 (≥65岁).
- 用sufentanil诱导的镇静,然后用remimazolam或propofol进行位,以修改观察者评估警觉/镇静量级得分<3.
- 主要结局:经手术后第3天的认知恢复,通过术后恢复质量表 (PostopQRS) 认知领域进行评估. 二级结局包括患者满意度和不良事件.
主要成果:
- 在手术后第三天的认知恢复在雷米马佐拉姆 (84.2%) 和普罗波 (85.1%) 组之间是相似的 (p = 0.854).
- 雷米马佐拉姆组报告患者满意度显著提高 (p = 0.001).
- 与普罗波 (所有p <0.05) 相比,雷米马佐兰与低血压 (21.9%与53.5%),低氧化 (6.1%与16.7%) 和注射部位疼痛 (15.8%与41.2%) 的发病率较低.
结论:
- 在接受结肠镜检查的老年患者中,雷米马佐拉姆的认知恢复与普罗波相似.
- 雷米马佐拉姆可以提高患者的满意度和更有利的安全性,包括降低低血压,低氧化和注射部位疼痛.
- 雷米马佐拉姆在老年人群中为程序性镇静提供了对普罗波福的有希望的替代品.
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