相关实验视频
Updated: Jun 4, 2025

08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
15.9K
类药物降低了与代谢功能障碍相关的脂肪性肝病中肝细胞癌的风险:系统性审查和元分析
Zahid Ijaz Tarar1, Umer Farooq2, Faisal Inayat3
1Department of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, United States.
World journal of experimental medicine
|December 23, 2024
概括
静止剂的使用显著降低了肝细胞癌 (HCC) 的风险,在患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者. 较高的累积剂量和脂友性他类药物显示出更大的HCC风险降低.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是慢性肝病的日益严重的原因,也是肝细胞癌 (HCC) 的风险因素.
- 类药物因其在癌症化学预防和治疗方面的潜力而得到认可.
- 类药物对MASLD患者HCC风险的具体影响仍在调查中.
研究的目的:
- 评估他类药物治疗对诊断为MASLD的个体中HCC发病率的影响.
- 为了比较脂友性和水友性他类药物之间的HCC风险降低.
- 评估累计他类药物剂量与HCC风险之间的相关性.
主要方法:
- 一项系统性审查和元分析综合了研究中的数据,研究了在MASLD患者中使用他类药物和HCC发生情况.
- 在他类药物使用者和非使用者之间计算了HCC风险差异.
- 亚组分析考虑了他类药物的脂友性和累积定义每日剂量 (cDDD).
主要成果:
- 分析包括了四项研究,涉及291,684名患者.
- 服用他类药物的MASLD患者的HCC风险总和降低了60% (RR = 0.40).
- 脂友性他类药物与降低HCC风险相关 (RR = 0.42),而水友性他类药物没有显著降低 (RR = 0.57).
- 较高的累积他类药物剂量 (>600cDDD) 显示出最显著的HCC风险降低 (RR = 0.30).
结论:
- 立方体治疗与在MASLD人群中患上HCC的风险降低有关.
- 降低HCC风险的程度受他类药物的累积剂量和脂性影响.
- 这些发现支持他类药物在MASLD患者中具有HCC风险的化学预防作用.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
531
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
531
Cholesterol: Significance and Regulation
501
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
501
Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Blood Studies for Cardiovascular System III: Serum Lipid Profile
131
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
131
Liver Physiology
419
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
419

