在口腔上皮质发育不良症和状细胞癌中对母细胞计数进行比较
Saede Atarbashi-Moghadam1, Maral Niazmand2, Shahla Vafadar1
1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of dentistry (Shiraz, Iran)
|December 23, 2024
概括
在炎症中至关重要的母细胞,在先发性白血病中比口腔状细胞癌 (SCC) 更多. 随着口腔癌的进展,它们的数量下降,这表明它们可能在早期病变发展中发挥作用.
科学领域:
- 口腔病理学 口腔病理学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 口腔状细胞癌 (OSCC) 和白血病是与慢性炎症相关的常见上皮病变.
- 乳腺细胞是炎症反应的关键发起者和传播者.
研究的目的:
- 在口腔状细胞癌 (SCC) 和失塑性白血病中量化巨细胞.
- 调查巨细胞在这些口腔病变的进展中的潜在作用.
主要方法:
- 一项回顾性横截面研究分析了63个档案病例:22个OSCC,28个失生性白血病 (表皮失生症) 和13个正常的口腔粘膜组织.
- 乳腺癌细胞使用托卢伊丁蓝色染色进行鉴定,在特定的热点区域进行高放大计数.
- 统计分析包括ANOVA和t测试,以比较巨细胞计数和炎症得分.
主要成果:
- 与异形性白血病 (p=0.009) 相比,OSCC中的巨细胞计数显著较低 (p=0.009).
- 没有发现巨细胞计数与炎症严重程度 (p=0.345) 之间有显著的相关性.
结论:
- 在前恶性失生性白血病中,母细胞数量比在侵入性OSCC中更高.
- 随着结缔组织的侵袭和口腔癌进展中的相关微环境变化,巨细胞的减少可能会发生.
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