相关实验视频

Updated: Jun 4, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

中国患者和患有类风湿性关节炎的美国患者之间恶性瘤的不同患病率和谱:一项比较研究

Zhi-Ming Ouyang¹, Yao-Wei Zou¹, Jie Pan¹

¹Department of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

|December 23, 2024

概括

与美国人相比,中国风湿性关节炎 (RA) 患者的恶性病发病率较低. 这些RA群体之间存在不同的风险因素,如年龄和抗CCP抗体,需要进行量身定制的查.

科学领域:

类风湿病学类风湿病学
在瘤学瘤学.
流行病学流行病学

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,与恶性瘤的风险增加有关.
了解不同种族的RA患者癌症患病率和风险因素的流行病学差异对于有针对性的干预至关重要.

研究的目的:

为了比较中国和美国患有类风湿关节炎的患者中恶性瘤的流行病学特征和相关因素.
在这两个不同的RA群体中确定癌症的不同风险因素.

主要方法:

来自国家健康和营养检查调查 (n=2,928) 的真实世界中国RA队列 (n=2,073) 和美国RA患者的回顾性分析.
用统计分析,包括多变量逻辑回归来比较恶性瘤的患病率,亚型和相关因素.

主要成果:

在匹配后,中国RA患者的恶性瘤患病率明显较低 (6.2%),而美国RA患者 (12.6%).
恶性瘤患病率的性别特异性差异被注意到,中国的男性倾向,美国的女性倾向.
在中国RA患者中,恶性瘤的关键关联因素包括年龄较大和阳性抗循环类抗体,而美国RA患者则与女性性别,年龄较大,活跃吸烟和心血管疾病有关.

结论:

在中国和美国的RA患者之间存在恶性瘤的流行率,亚型和危险因素的实质性差异.
这些发现强调了为RA患者根据其种族和人口特征制定个性化恶性查策略的重要性.

关键词:

美国人美国人美国人华人中文华人中文是什么意思恶性瘤是一种恶性瘤.类风湿性关节炎类风湿性关节炎类风湿性关节炎

更多相关视频

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...