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Updated: Jun 4, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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通过与氨基酸一起形成共晶来优化theophylline的物理化学性质

Qi Li1, Yifei Xie2, Zhipeng Wang1

  • 1Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 P.R. China ydz@imm.ac.cn.

RSC advances
|December 23, 2024
PubMed
概括

合成了氨酸 (GABA) 和氨酸 (ARG) 的新型神素 (THE) 和氨酸 (GABA) 的共晶体. 这些共同晶体增强了 THE.

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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