在遗传性和异常性帕金森病中大脑年龄
Stefan J Teipel1,2, Hauke Hoffmann2, Alexander Storch1,3
1Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock-Greifswald, Rostock 18147, Germany.
Brain communications
|December 23, 2024
概括
大脑年龄差距,大脑完整性的衡量标准,在帕金森病和阿尔茨海默病之间有所不同. 在帕金森氏症中,大脑年龄差距与更快的认知和运动衰退以及类似阿尔茨海默氏症的病理相关.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 大脑衰老 老龄化
背景情况:
- 由结构性MRI得出的大脑年龄差距估计了大脑的完整性,并与神经退行性疾病有关.
- 它在帕金森病 (PD) 中的实用性,特别是遗传形式,以及它与阿尔茨海默病 (AD) 病理学的关联需要进一步调查.
研究的目的:
- 为了评估与对照组相比,异常性PD,LRRK2和GBA突变携带者的大脑年龄差距.
- 调查大脑年龄差距与AD/PD生物标志物之间的关联.
- 检查大脑年龄差距与认知/运动衰退率之间的关系.
主要方法:
- 利用了来自帕金森氏症进展标志物倡议的1200个PD病例 (原发病,LRRK2,GBA) 和对照组的队列.
- 包括187名阿尔茨海默氏症痴呆病例和254名来自阿尔茨海默氏症神经成像倡议的对照.
- 采用贝叶斯式ANOVA和通用线性混合效应模型来分析大脑年龄差距的关联.
主要成果:
- 异形性PD显示大脑年龄差距为0.7年,而AD痴呆病例显示为5.9年的差距.
- 无症状LRRK2载体的脑年比对照组年轻1.1年.
- 较高的大脑年龄差距与运动障碍相关,多巴胺转运器活性降低,PD的认知/运动衰退更快,但与AD病理标志物有关.
结论:
- 大脑年龄似乎对AD类缩更敏感,而不是PD类变化.
- 在异常性PD中,大脑年龄与AD标志物有关,而不是PD标志物.
- "大脑年龄"的概念在某些疾病阶段可能会误导,因为反应性大脑变化可能会膨胀年龄估计.
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