相关实验视频

Updated: Jun 4, 2025

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

通过质子核磁共振分析,在人类尿样中的草甘基除草剂代谢资料

Preechaya Tajai^1,2, Giatgong Konguthaithip^1,2, Thanyaphisit Chaikhaeng³

¹Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

|December 23, 2024

概括

这项研究提供了证据表明草甘 (GLY) 可能在人类中代谢. 研究人员在园艺工人的尿样中检测到GLY及其代谢物,这表明人类代谢这种常见的除草剂.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生物化学生物化学

背景情况:

草甘基除草剂在全球广泛使用.
由于在体液中检测到草甘,人们对潜在的人类健康风险存在担忧.
关于人类草甘代谢的数据有限.

研究的目的:

为了调查草甘 (GLY) 是否在人类中发生代谢.
在人类生物样本中识别潜在的GLY代谢物.
解决人类草甘代谢的关键知识差距.

主要方法:

对八名便利园艺工人的草甘及其代谢物的分析.
使用质子核磁共振 (1H-NMR) 光谱仪进行数据分析.
在除草剂应用之前和之后收集多个点滴尿样.

主要成果:

在尿样中检测到草甘 (GLY) 和其代谢物,包括AMPA,甲,沙科辛,甘酸和甲基胺.
观察到GLY中位数度与其已识别的代谢物之间的中等相关性.
证实了GLY及其代谢副产品在人体泌尿系统中的存在.

结论:

提供了令人信服的证据,表明人类可能会代谢草甘 (GLY).
1H-NMR数据分析显示,这是一种研究人类GLY代谢的技术.
这些发现为人类尿液排泄GLY及其代谢物的模式提供了宝贵的见解.

关键词:

基于1H-NMR的代谢组分.它的代谢物是代谢物.杀虫剂杀虫剂杀虫剂有毒性有毒性有毒性有毒性.

更多相关视频

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Published on: January 10, 2022

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Published on: May 20, 2013

相关概念视频

Proton (¹H) NMR: Chemical Shift

Proton (¹H) NMR: Chemical Shift

Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei...