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Updated: Jun 4, 2025

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SARS-CoV-2 Nsp14结合Tollip并激活促炎途径,同时降低干扰素α和干扰素γ受体的调节

Naveen Thakur1, Poushali Chakraborty1, JoAnn M Tufariello1

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

bioRxiv : the preprint server for biology
|December 23, 2024
PubMed
概括

SARS-CoV-2 Nsp14蛋白激活免疫信号通路并降低干扰素受体的调节. 它的N7-MTase域对这些功能和与宿主蛋白Tollip的相互作用至关重要,有助于病毒免疫逃避.

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