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Updated: Jun 4, 2025

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

Published on: May 5, 2022

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影响基因素乙化的化学扰动控制着结直肠癌分化

Pornlada Likasitwatanakul1,2,3,4, Zhixin Li1,2,3, Paul Doan1,3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

bioRxiv : the preprint server for biology
|December 23, 2024
PubMed
概括

抑制基因组脱乙酶 (HDAC) 1/2通过改变基因组乙化来促进结直肠癌 (CRC) 的分化和抗瘤活性. 这种表观遗传重编程突出了CRC的潜在治疗策略.

关键词:
结肠直肠癌是什么意思表观遗传调节 表观遗传调节肠道分化 肠道分化干细胞是一种干细胞.

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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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