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Updated: Jun 4, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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3-thio-3,4,5-trisubstituted-1,2,4-triazoles:高亲和度的体静止素受体-4主因子合成和结构-活性关系

A Michael Crider1, Audrey Hospital1, Karin E Sandoval1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA mcrider@siue.edu.

RSC medicinal chemistry
|December 23, 2024
PubMed
概括

研究人员发现了新型的3-thio-1,2,4-triazole化合物,这些化合物作为索马托斯塔丁受体-4 (SST4) 的强效和选择性激动剂. 这些化合物对阿尔茨海默病和疼痛等疾病具有显著的治疗潜力.

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