在患有膜肺狭窄症的成人中,心脏功能和临床指数的时间变化
Alexander C Egbe1, C Charles Jain1, Luke J Burchill1
1From the Department of Cardiovascular Medicine, Mayo Clinic Rochester, MN, 55905, USA.
International journal of cardiology. Congenital heart disease
|December 23, 2024
概括
与已修复的法洛四重症 (TOF) 相比,患有缓解性肺狭窄症 (PVS) 的患者表现出较慢的心脏重塑和疾病进展. 这表明PVS患者可能需要更少的临床和成像随访.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 医疗成像医学成像
背景情况:
- 肺狭窄症 (PVS) 缓解导致心脏重塑比修复的法洛四重法 (TOF) 较少.
- 心脏重塑和疾病进展的比较速度在PVS与TOF与类似的右心室外流通道 (RVOT) 疾病是未知的.
- 这项研究比较了患有缓解PVS和修复TOF的中度/重度RVOT疾病的成年人的时间变化.
研究的目的:
- 为了比较心脏重塑的速度随着时间的推移在患者与息PVS与修复TOF.
- 评估PVS和TOF组之间的临床和心脏功能指数进展的差异.
- 评估两组患者心血管不良事件的发生率.
主要方法:
- 应变成像评估了心脏功能,以及临床指数:NT-proBNP,MELD-XI和峰值VO2.
- 测量是在基线,3年和5年进行的,时间变化是从基线的相对变化计算的.
- 心血管不良事件被追踪为时间到事件的结果.
主要成果:
- 与TOF组相比,PVS组在5年内对右心房水库菌株,RV自由壁菌株,NT-proBNP,MELD-XI和VO2峰值的时间变化明显较小.
- 五年内心血管不良事件的发生率在PVS组 (76%) 比TOF组 (54%) 高.
- 在所有关键比较发现中观察到统计学意义 (p < 0.05).
结论:
- 化PVS患者的心脏重塑和疾病进展速度比修复TOF患者慢.
- 这些发现表明,对于PVS患者来说,可能适合较少密集的随访时间表.
- 这些结果对优化先天性心脏病幸存者的长期管理策略有意义.
更多相关视频
10:33Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
27.6K
12:12Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
15.9K
相关概念视频
01:25Cardiovascular System Abnormal Findings II: Auscultation
100
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Abnormal Heart Sounds
Gallops:
100
01:17Assessment of apical pulse
827
Assessing the Apical Pulse
Assessing the apical pulse is a critical nursing procedure, particularly indicated for:
Assessing the apical pulse is a critical nursing procedure, particularly indicated for:
827
01:25Assessment of the Cardiovascular System IV: Auscultation
210
Cardiac auscultation is a clinical skill used to assess heart function and detect abnormalities. It involves listening to heart sounds at specific anatomical locations through a stethoscope.
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
210