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Updated: Jun 4, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

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对于选择性O-GlcNAcase抑制剂Thiamet-G的高效和可访问的六度图尺度合成

Viktor Holicek1, Matthew Deen1, Sandeep Bhosale1

  • 1Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5S 1P6, Canada.

ACS omega
|December 23, 2024
PubMed
概括

研究人员开发了一种可扩展的方法来产生Thiamet-G,Thiamet-G是一种关键的抑制剂,用于研究疾病中的O-链接β-N-乙糖胺 (O-GlcNAc). 这种具有成本效益的合成为动物研究提供了大量的OGA抑制剂.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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