结构聚合物使得在关节内空间内的葡萄皮质激素的持续输送成为可能
Ana Crastin1, Claire S Martin2, Sai Suresh1
1Dept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Advanced healthcare materials
|December 23, 2024
概括
凝剪切水凝 (GSHs) 为关节炎提供延长的关节内葡萄糖皮质体输送. 在临床前模型中,这些可注射的水凝显示出持续的普雷尼索隆释放,并有效地减少关节炎症和退行.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 类风湿病学 类风湿病学
背景情况:
- 关节内葡萄糖皮质体注射可以治疗关节炎,但作用短暂,并有可能损伤关节.
- 目前的水凝限制包括in situ凝问题,限制了关节内应用.
- 盖伦剪切水凝 (GSHs) 提供剪切稀释和重组,以增强关节内居住.
研究的目的:
- 调查GSHs对于延长的普雷迪尼索隆的关节内输送.
- 为了关联材料力学,类固醇释放和临床前疗效.
- 为了评估 GSHs 在 synoviocyte 培养和小鼠关节炎模型.
主要方法:
- 用于关节内布雷迪尼索隆递送的GSHs的配方 (10 mg/mL).
- 评估药物释放特征和延长培养中的稳定性.
- 细胞兼容性和抗炎作用在同胞细胞中的评价.
- 在转基因 (TNF) 197Gkl (TNFtg) 关节炎小鼠模型中进行临床前疗效测试.
主要成果:
- 在Fickian扩散的18天内,GSHs表现出持续的普雷尼索隆释放.
- 系统稳定,生物相容,并抑制了炎症性协同细胞激活.
- 在TNFtg小鼠中,GSHs显著减少了突炎,松形成,并保留了关节软骨.
结论:
- 可注射的GSH配方提供延长的关节内类固醇释放.
- 在长期管理炎症性关节炎症 (如类风湿性关节炎和骨关节炎) 方面,GSHs显得有前途.
- 这代表了关节炎的关节内药物输送的重大进步.
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