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Updated: Jun 18, 2026

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
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基于Caco-2的肠粘膜模型的开发,以研究肠壁特性和细菌-粘液相互作用

Evelien Floor1, Jinyi Su2, Maitrayee Chatterjee2,3

  • 1Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Gut microbes
|December 23, 2024
PubMed
概括

研究人员开发了一种新的体外肠道模型,使用在空气-液体接口 (ALI) 下培养的Caco-2细胞与血管肠道 (VIP) 进行培养. 这种方法成功地产生了粘液层,改善了用于研究宿主微生物群相互作用和屏障功能的仿生特征.

关键词:
阿里阿里是什么意思?欧洲经济共同体 欧洲经济共同体 欧洲经济共同体牛奶植物植物菌植物植物 (Lactiplantibacillus plantarum) 是一种植物.在MUC2中,MUC2是MUC2.粘液 粘液是一种粘液.沙门氏菌输入菌血清 Enteritidis 输入菌一个VIP的VIP的VIP的空气液体增长的增长.在芯片上的肠道.肠道粘膜中的肠道粘膜.紧密的结节 紧密的结节在Transwell,我们可以看到.

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...