使用气体囊泡进行超高频超声波的压力估计
Eric M Strohm1,2,3, Di Wu4, Dina Malounda4
1Department of Physics, Toronto Metropolitan University (formerly Ryerson University), Toronto, Ontario M5B 2K3, Canada.
The Journal of the Acoustical Society of America
|December 23, 2024
概括
这项研究引入了一种使用气囊纳米结构 (GVs) 的新方法,以准确测量超高频超声传感器的输出压力. 该技术量化了传感器压力,这对于高分辨率声学显微镜应用至关重要.
科学领域:
- 生物物理学的生物物理.
- 声学 声学 在声学上
- 材料科学 材料科学 材料科学
背景情况:
- 声学显微镜使用超高频 (UHF) 超声传感器 (>80 MHz) 进行高分辨率成像.
- 这些超高频传感器的压力输出值在很大程度上是未知的,因为传统的校准水电话的局限性,通常测量高达80MHz.
研究的目的:
- 开发和验证一种新的方法来估计40-375 MHz频率的超高频超声传感器的压力输出.
- 为了解决用于先进成像应用的声压量化的挑战.
主要方法:
- 使用已知压力崩值 (571 kPa) 的气囊纳米结构 (GVs) 作为生物传感器.
- 将GV嵌入到阿加罗斯幻体中,并使用不同电压的UHF传感器对其进行扫描,以确定崩值.
- 假设传感器电压和声压之间的线性关系来计算输出压力.
主要成果:
- 开发的方法成功估计了超高频频率 (40,80,200和375 MHz) 的传感器压力.
- 对于40MHz传感器 (2.2 ± 0.1 MPa) 的压力测量与水电声测量 (2.1 ± 0.3 MPa) 非常相匹配,验证了基于GV的方法.
- 计算的压力为2.0 ± 0.1 MPa (80 MHz),1.2 ± 0.1 MPa (200 MHz) 和1.05 ± 0.17 MPa (375 MHz) 这三种.
结论:
- 气囊纳米结构为量化超高频超声波传感器的压力输出提供了一种可行的方法.
- 这种技术克服了当前水电话技术的局限性,为先进的超声波成像提供了准确的压力测量.
- 该研究成功地证明了40-400 MHz范围内的压力定量,为改善超高频超声波系统的特性铺平了道路.
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