在慢性非癌症疼痛人口中,与阿片类药物暴露有关的患者特征
Henrik Grelz1,2, Ulf Jakobsson2, Patrik Midlöv2
1Department of Clinical Sciences Malmö, Center for Primary Health Care Research, Lund University, Jan Waldenströms Gata 35, 202 13 Malmö, Sweden.
Scandinavian journal of pain
|December 23, 2024
概括
长期阿片类药物治疗 (LTOT) 治疗慢性非癌症疼痛 (CnCP) 与较高的阿片类药物剂量和风险增加有关. bensodiazepine 使用和男性性别与LTOT和较高的阿片类药物剂量有关,这表明潜在的安全问题.
科学领域:
- 疼痛医学 医学 疼痛医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 长期阿片类药物治疗 (LTOT) 治疗慢性非癌症疼痛 (CnCP) 具有可疑的疗效和确定的风险.
- 了解与LTOT和高阿片类药物剂量相关的患者特征对于降低风险至关重要.
- 阿片类药物使用障碍和过量服用风险需要仔细评估治疗模式.
研究的目的:
- 将LTOT患者的特征与未暴露患者的特征进行比较.
- 为了确定患有阿片类药物使用障碍或过量服用阿片类药物暴露患者的风险因素,特别是与剂量有关的风险因素.
- 分析LTOT对阿片类药物剂量和相关并发症的影响.
主要方法:
- 瑞典三级疼痛康复诊所的1604名成人CnCP患者 (2018-2020) 的横截面研究.
- 与瑞典处方药登记处的数据链接,以获取处方阿片类药物信息.
- 分析LTOT状态和阿片类药物剂量 (毫克吗啡相当/天[MME/天]),比较<50MME/天与≥50MME/天.
主要成果:
- 26.4%的患者接受了LTOT;89名患者的剂量≥50MME/天.
- LTOT与使用二zepine (OR 2.685) 和男性性别 (OR 1.694) 的几率增加有关.
- 患有≥50MME/天阿片类药物剂量的患者主要是使用LTOT,并且使用二胺和男性性别的几率更高.
结论:
- 长期的阿片类药物治疗显著影响处方阿片类药物的剂量.
- 同时使用二甲和男性性别在LTOT患者和高阿片剂量 (≥50MME/天) 的患者中过度代表.
- 这些发现突出了与慢性疼痛管理中高风险阿片类药物处方相关的关键因素.
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