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Updated: Jun 4, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Published on: June 26, 2018

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神经元构成性内分泌体穿孔使得α-同核素通过内部化的PFFs聚合

Anwesha Sanyal1,2, Gustavo Scanavachi1,2, Elliott Somerville2

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

The Journal of cell biology
|December 23, 2024
PubMed
概括

帕金森病涉及有毒的α-synuclein (α-syn) 聚合物. 这项研究揭示了神经元中的穿孔内分泌体,促进α-syn聚合和神经元死亡,提供了潜在的治疗点.

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