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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

5.9K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
5.9K
Nucleic Acids02:43

Nucleic Acids

43.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
43.6K
RNA-seq03:21

RNA-seq

9.8K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.8K
Types of RNA01:20

Types of RNA

5.6K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.6K
Nucleic acids02:43

Nucleic acids

159.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
159.6K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

11.9K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
11.9K

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相关实验视频

Updated: Jun 4, 2025

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.4K

在匹配和RNA中结束的模式.

Célia Biane1, Greg Hampikian2, Sergey Kirgizov1

  • 1Laboratoire d'Informatique de Bourgogne, Université de Bourgogne, Dijon Cedex, France.

Journal of computational biology : a journal of computational molecular cell biology
|December 23, 2024
PubMed
概括

在RNA结构中,末端粘附模式与理论匹配相比,显示出明显的分布. 这项研究分析了RNA中的21和12模式,突出了它们发生频率的差异.

科学领域:

  • 计算生物学和生物信息学
  • 结构RNA生物学 结构RNA生物学
  • 组合学是一种组合学.

背景情况:

  • 终端粘附模式是连续开始和结束点的匹配弧的子集,对应于 permutations.
  • 了解RNA结构中的模式发生,特别是那些具有伪结的结构,对于破译RNA功能至关重要.
  • 之前的研究已经确定了端附着模式和排列之间的一对一对应.

研究的目的:

  • 在理论匹配和现实世界RNA结构中研究特定的末端粘附模式 (21和12) 的频率和分布.
  • 分析这些模式的组合性质和非对称行为.
  • 检查"延伸扭曲"转换对尺寸3的模式的影响.

主要方法:

  • 在匹配中对终端粘附模式的组合分析.
  • 统计检查原生RNA二次结构中的模式分布,包括具有伪结的结构.
  • 理论模型与实证RNA数据之间的模式频率的比较.

主要成果:

  • 图案21 (两个连续的基对) 和12 (最小的伪结) 在理论匹配中均等分布.
  • 这种均等分布与原生RNA结构中观察到的频率形成显著对比.
  • 分析了尺寸3的末端粘附模式的分布,包括它们在末端扭曲转换下的行为.
关键词:
这是一个RNARNARNARNARNA.组合学是一种组合学.匹配的匹配匹配的匹配图案 图案 模式 模式 模式二级结构是二级结构的二次结构.

更多相关视频

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

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相关实验视频

Last Updated: Jun 4, 2025

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.4K

结论:

  • 结尾粘附模式在匹配与本地RNA的明显分布表明RNA具有独特的进化或功能约束.
  • 这些发现为RNA分子的结构偏差和偏好提供了见解.
  • 进一步的研究可以探索这些模式分布对RNA折叠,功能和设计的影响.