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在1型糖尿病的老年人中自动提供胰岛素
Yogish C Kudva1, Robert J Henderson2, Lauren G Kanapka2
1Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
自动注射胰岛素显著降低了1型糖尿病老年人的低血糖. 与传统方法相比,这种先进技术提供了更好的血糖控制和安全性.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 医疗技术 医疗技术 医学技术
背景情况:
- 患有1型糖尿病的老年人面临严重低血糖的风险增加.
- 自动化胰岛素输送系统 (AID) 在减轻这些风险方面表现有前途.
- 有限的研究存在于这种特定的人群中AID的有效性和安全性.
研究的目的:
- 评估自动化胰岛素输送系统在降低1型糖尿病老年人低血糖的有效性.
- 为了比较混合闭环 (HCL) 和预测低葡萄糖悬浮 (PLGS) 系统与传感器增强 (SAP) 治疗的性能.
主要方法:
- 一个多中心,随机交叉试验,涉及65岁及以上的1型糖尿病成年人.
- 参与者经历了三个12周的治疗期:HCL,PLGS和SAP,随机排序.
- 衡量的主要结果是葡萄糖水平保持在70 mg/dl以下的百分比时间.
主要成果:
- 与SAP治疗相比,AID系统 (HCL和PLGS) 显著减少了与70 mg/dl以下的葡萄糖水平相比的时间 (P<0.001).
- 在70 mg/dl以下的时间内,HCL治疗与SAP治疗的平均差异为-1.05个百分点.
- 与SAP相比,HCL改善了目标葡萄糖范围 (70-180 mg/dl) 的时间,平均差异为8.9个百分点.
结论:
- 自动注射胰岛素有效降低1型糖尿病老年人的低血糖.
- 与SAP相比,HCL和PLGS系统都显示出更好的血糖控制和安全配置文件.
- 在老年人群中,AID代表了管理1型糖尿病的有价值的治疗进步.
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