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侵入性或非侵入性迷走神经刺激,大脑功能调节和中风后重塑:一篇综述

Jun Zhang^1,2,3,4,5,6, Fengyuan Zhou^2,3,4,5,6, Neil Roberts⁷

¹Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International journal of surgery (London, England)

|December 23, 2024

概括

迷你神经刺激 (VNS) 显示出改善中风患者神经缺陷的前景. 需要进一步的研究来优化VNS参数,并探索其在出血性中风康复中的应用.

科学领域:

神经科学是一个神经科学.
康复医学康复医学康复医学
生物医学工程生物医学工程

背景情况:

神经学缺陷显著阻碍了中风患者的重返社会.
神经刺激 (VNS) 正在研究其维持神经改善的潜力.
了解VNS机制,有效性和安全性对于中风康复至关重要.

研究的目的:

总结关于中风VNS机制,疗效和安全性的研究.
为了确定未来VNS应用中风恢复的研究差距.
为随后的VNS研究和临床使用提供参考.

主要方法:

在PubMed,Web of Science,Embase和Ovid MEDLINE进行系统的文献搜索.
根据标题和摘要,对1866个出版物的初步选.
253篇相关论文的全文审查和评估,以获得资格.

主要成果:

62项研究符合中风康复中VNS的资格标准.
侵入性和非侵入性VNS通过突触可塑性,减少炎症,血管再生和血脑屏障保护来调节大脑功能.
侵入性VNS在缺血性中风中对上肢动力障碍有希望; 穿皮VNS也显示出治疗效果.

结论:

神经刺激 (VNS) 是中风康复的一种有前途的治疗方法.
优化VNS参数,刺激时间和应用地点需要进一步开发.
对于出血性中风的VNS的使用仍然未被探索,需要在未来进行研究.

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