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Updated: Jun 4, 2025

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
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使用由带衍生的生物3D导管的神经再生 - - 在老鼠坐骨神经缺陷模型中衍生出介质干细胞

Terunobu Iwai1, Ryosuke Ikeguchi1,2, Tomoki Aoyama3

  • 1Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan.

PloS one
|December 23, 2024
PubMed
概括

生物3D导管是由人类带衍生中细胞 (UC-MSCs) 制成的,在老鼠中显示出有前途的神经再生. 这些导管的性能优于管,并与自身移植结果相匹配,具有抑制的免疫排斥,突出显示UC-MSCs是神经修复的可行来源.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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