维生素D受体基因多态和基本高血压之间的关联:更新的系统性审查,元分析和元回归
Iwan Dakota1, Muhamad Fajri Adda'i1, Rido Maulana1
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia.
PloS one
|December 23, 2024
概括
维生素D受体基因变异和基本高血压风险是有争议的. 一项元分析发现了BSMI的多态性.
科学领域:
- 遗传学 遗传学 是一个
- 心血管疾病 心血管疾病
- 分子生物学分子生物学
背景情况:
- 基本高血压 (EH) 是一种复杂的心血管疾病,具有多因素的病因.
- 维生素D受体 (VDR) 基因在平衡和血压调节中起作用.
- 之前关于VDR基因多态和EH之间的关联的研究已经产生了相互矛盾的结果.
研究的目的:
- 进行全面的元分析,评估VDR基因多态 (BsmI,FokI,ApaI,TaqI) 与基本高血压之间的关联.
- 调查VDR-EH协会中潜在的异质性来源,包括研究质量,性别和年龄.
主要方法:
- 在多个数据库 (PubMed,Cochrane,EMBASE等) 的系统文献搜索. 坚持PRISMA指南的使用.
- 来自13个国家的22项研究的元分析,根据各种遗传模型 (等位基因,附加基因,主导基因,衰退基因) 计算聚合几率比率 (OR).
- 进行元回归分析,以探索异质性和方法因素的影响.
主要成果:
- 在一个衰退模型下,BSMI多态性与显著降低EH风险相关 (OR:0.81;95%CI,0.69至0.94).
- 对于FokI,ApaI和TaqI多态与EH风险没有观察到任何显著的关联.
- 研究质量,男性比例和年龄被确定为FokI多态与EH风险相关的显著调节因素.
结论:
- BsmI VDR基因多态性,特别是在衰退性同胞体中,独立地与降低基本高血压风险有关.
- 福基VDR基因多态性对EH风险的影响是由研究质量,性别和年龄调节的.
- 需要进一步的研究,以阐明这些高血压遗传关联背后的确切机制.
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