在患有蛋白质丧失肠道病变的狗中,普雷迪尼索隆的药理动力学
Sara A Jablonski1, Jessica L Strohmeyer1, John P Buchweitz2
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
葡萄糖皮质激素的吸收不良不太可能导致蛋白质丧失肠病症 (PLE) 的狗的治疗失败. 研究表明,PLE犬和健康对照犬的药物暴露程度相似,尽管PLE犬的普得尼索隆药理学发生了变化.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 狗的蛋白质丧失肠道病变 (PLE) 的治疗失败率很高,约为50%.
- 葡萄糖皮质类药物吸收不良在这种治疗失败中的作用目前尚不清楚.
研究的目的:
- 为了比较口服布雷迪尼索隆的药理动力学 (PK) 在有PLE的狗和健康对照中.
- 调查药物吸收的改变是否有助于犬类PLE的治疗耐药性.
主要方法:
- 一项前性病例对照研究,涉及14只患有PLE的狗和7只健康的对照.
- 狗每天一次口服1毫克/千克的普雷迪尼索隆,持续三周.
- 血清药物度在多个时间点测量,以获得PK变量,包括半衰期和非蛋白质结合分数.
主要成果:
- 与对照组相比,患有PLE的狗表现出较短的普雷尼索隆半衰期和较高的非蛋白质结合血清普雷尼索隆百分比.
- 尽管存在这些PK差异,但在PLE犬和对照犬之间,普德尼索隆总暴露和血清度峰值并没有显著差异.
- 在PLE组中,短期响应者和非响应者之间没有观察到药物暴露的显著差异.
结论:
- 口服普得尼索隆暴露在患有PLE的狗和健康对照犬之间是可比的.
- 葡萄糖皮质激素的吸收不良不太可能是治疗失败的常见原因在犬类蛋白质丧失肠道病变.
- 可能需要进一步的研究来确定其他导致PLE治疗耐药性的因素.
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