COVID-19感染对多发性硬化症症状严重程度和残疾的影响
Amber Salter1,2, Samantha Lancia1, Gary R Cutter3
1Department of Neurology, Section on Statistical Planning and Analysis, University of Texas Southwestern Medical Center, Dallas.
Neurology
|December 23, 2024
概括
在一项纵向研究中,COVID-19感染并没有显著改变多发性硬化症 (MS) 症状严重程度或残疾进展. 这项研究阐明了SARS-CoV-2对MS患者结局的影响.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 感染,包括SARS-CoV-2 (COVID-19),可能会影响多发性硬化症 (MS) 的发展.
- 之前对COVID-19对MS结果的影响的研究表明,样本规模很小,结果相互矛盾.
- 了解COVID-19和MS轨迹之间的关联对于患者管理至关重要.
研究的目的:
- 评估COVID-19感染与MS症状严重程度的变化之间的关联.
- 评估COVID-19感染对MS患者残疾轨迹的影响.
- 提供关于COVID-19在多发性硬化症患者群体中的后果的可靠数据.
主要方法:
- 使用受控中断时间序列 (ITS) 设计,使用来自北美多发性硬化症注册研究委员会的纵向数据.
- 包括至少有三个感染前和感染后调查答案的参与者.
- 使用SymptoMScreen (SMSS) 测量症状严重程度,使用患者衍生残疾分数 (PDDS) 测量残疾,通过细分回归分析变化.
主要成果:
- COVID-19感染与症状严重程度 (SMSS得分) 或残疾的立即变化无关.
- 随着时间的推移,症状严重程度和残疾的轨迹在COVID-19感染队列和未感染队列之间没有显著差异.
- 随访期间的中位数为18个月,结果在症状和残疾指标上一致.
结论:
- 在患有MS的人群中,COVID-19感染似乎不会立即改变症状严重程度或残疾.
- 在COVID-19感染后,MS症状和残疾的长期发展轨迹在很大程度上保持不变.
- 这些发现有助于更好地了解MS患者感染结果,尽管可能不适用于所有年龄组.
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