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Updated: Jun 4, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Published on: July 25, 2020

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针对性剂持续重新评估方法:用于分子向疗法的第一阶段试验的新贝叶斯式丰富设计

Clement Ma1,2, David S Shulman1,2, Hasan Al-Sayegh1

  • 1Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA.

JCO precision oncology
|December 23, 2024
PubMed
概括

新型的TARGET-CRM设计改善了早期阶段试验中罕见基因组改变的癌症患者的入学情况. 与传统设计相比,这种自适应方法优化了剂量发现,同时保持了试验的安全性和准确性.

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