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甲酸代谢产物与8-19岁儿童的身体组成之间的关联

Zhi Li¹, Yu Han¹, Xiaoqing Huang¹

¹Department of Maternal, Child and Adolescent Health, School of Public Health, Tianjin Medical University, Tianjin, China.

International journal of environmental health research

|December 23, 2024

概括

酸盐代谢产物可能会对儿童的骨密度和肌肉质量产生负面影响,特别是在男性中. 这项研究强调了这些常见化学物质对青少年身体组成的潜在性别特异性影响.

科学领域:

环境健康环境健康
儿科内分泌学儿科内分泌学
毒理学毒理学毒理学

背景情况:

酸盐是广泛使用的化学物质,具有潜在的内分泌干扰性质.
儿童和青少年接触酸盐是常见的.
人们对甲酸盐代谢产物对人体成分的综合影响知之甚少.

研究的目的:

调查单个和组合的甲酸代谢产物与儿童和青少年的身体组成之间的关联.
探索甲酸代谢物对人体组成的潜在性别特异性影响.
检查发育阶段是否影响这些关联.

主要方法:

利用了2015-2018年国家健康和营养检查调查 (NHANES) 的数据.
采用单次暴露分析,量子式g计算和贝叶斯核心机器回归.
进行了性别分层和发育阶段分层分析.

主要成果:

大多数甲酸盐代谢物与区域骨矿物质密度 (aBMD) 有负相关性.
一种甲酸代谢物的混合物与aBMD有负面关联.
单乙甲酸 (MBP),单乙甲酸 (MEP) 和单异乙甲酸 (MiBP) 与男性的瘦身量有负面联系,但与女性无关.
这些关联在整个童年和青春期都是一致的.

结论:

酸盐代谢产物可能会对儿童和青少年的身体组成产生不利影响,特别是aBMD.
特定的甲酸代谢产物显示出与身体成分的性别特异关联.
男性似乎对某些甲酸盐代谢产物对瘦肉质的影响更敏感.

关键词:

BKMR BKMR 在线播放尼汉斯 (NHANES) 是一个名人.甲酸的含量甲酸的含量身体构成身体组成混合物混合物混合物

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