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Updated: Jun 4, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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改进了使用对比学习与结构推理进行的酶功能注释预测

Yuxin Yang1,2,3, Abby Jerger4, Song Feng5

  • 1Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Communications biology
|December 23, 2024
PubMed
概括

这项研究介绍了CLEAN-Contact,这是一种新的深度学习方法,通过整合氨基酸序列和蛋白质结构来预测酶功能的功能. 与现有方法相比,这种方法显著提高了预测准确度.

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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Structural Classification of Joints01:20

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A fibrous joint is where the adjacent bones are united by fibrous connective...
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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
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Predicting Reaction Outcomes02:24

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Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
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When a nucleophile and an alkyl halide react, nucleophilic substitution and β-elimination reactions compete to generate products.
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