外源性孕激素发射的12小时差异对人工周期中的持续怀孕率没有影响,只要在胚胎细胞转移前五天开始乳腺期支持,就不会影响人工周期中的持续怀孕率
Cristina Rodríguez-Varela1, Maria Salvaleda-Mateu2, Ernesto Bosch2,3
1Global Research Alliance - IVI Foundation (IIS La Fe). Research Department, Avinguda de Fernando Abril Martorell, 106. 46026, Valencia, Spain. cristina.rodriguez@ivirma.com.
在胚胎移植 (ET) 前五天早上或晚上开始发育激素 (P4),不会影响人工周期中的持续怀孕率. 这一发现为治疗不孕症患者的患者管理提供了灵活性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 外源性孕激素 (P4) 在胚胎移植 (ET) 期间的人造周期中对质期支持 (LPS) 至关重要.
- 启动P4的时间,特别是早上与晚上,可能会影响治疗结果,但证据有限.
研究的目的:
- 为了确定是否启动外源P4的时间 (早上与晚上) 在胚胎细胞ET前五天的影响正在进行的怀孕率 (OPR) 在人工周期.
主要方法:
- 一项回顾性队列研究分析了6493个接受ET的人工循环.
- 用微化阴道孕激素 (MVP) 进行状期支持 (LPS),从ET前五天开始.
- 周期按LPS的"早上开始" (2021年4月以来) 或"晚上开始" (2021年3月之前) 分类.
主要成果:
- 在上午 (46.9%) 和晚上 (46.3%) P4启动 (p=0.682) 之间没有观察到OPR的显著差异.
- 调整后的分析证实时间对OPR没有影响 (aOR:1.00;p=0.996).
- 在ET日的血清P4水平在两组之间相似 (13.4 ± 5.8 ng/ml对比13.2 ± 6.4 ng/ml; p=0.181),尽管在早上开始时,亚最佳水平 (<8.8 ng/ml) 的频率略低 (16.6%对比19.8%; p=0.001).
结论:
- 在开始外源P4的12小时的差异不会影响人工周期的怀孕结果,如果在ET前5天开始.
- 这一发现为临床医生和患者提供了灵活性,允许在早上或晚上启动LPS.
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