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在儿科人口中,在蜂毒免疫疗法期间出现过敏反应

Jessica W S Wong¹, Ashling Courtney¹, Tess O'Gorman¹

¹Department of Immunology, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Journal of paediatrics and child health

|December 23, 2024

概括

在蜂毒免疫疗法 (BVIT) 期间经历过敏反应的儿童继续治疗的风险较低. 然而,在维护BVIT期间出现过敏反应的人不太可能耐受持续的免疫治疗.

科学领域:

过敏和免疫学过敏和免疫学
儿科过敏儿科过敏
免疫治疗是一种免疫疗法.

背景情况:

蜜蜂毒液免疫疗法 (BVIT) 是一种常见的治疗方法,用于对白虫毒液过敏.
过敏反应是BVIT期间的潜在不良事件,需要谨慎管理.
了解过敏反应后的结果对于优化BVIT协议至关重要.

研究的目的:

在儿科BVIT期间审查过敏反应发作.
分析过敏反应后的剂量计划修改和结果.
评估在患有过敏反应的儿童中BVIT的安全性和耐受性.

主要方法:

在西澳大利亚从2012年至2021年接受BVIT的儿童的回顾性研究.
收集的数据包括患者人口统计,过敏反应时的剂量和BVIT疗程修改.
评估的结果包括BVIT的延续,修改或终止以及随后的耐受性.

主要成果:

在624名儿童中,1.9%的儿童没有完成BVIT,主要是由于不遵守.
5.2% (33名儿童) 经历了36次过敏反应,主要发生在第一天 (56%).
在积累阶段经历过敏反应的儿童在当天继续 (83.3%) 或重新开始 (64.7%) 时有良好的耐受性;50%的维护阶段过敏反应患者可以容忍持续的免疫治疗.

结论:

积累阶段过敏反应的儿童通常可以安全地继续或重新启动BVIT.
在BVIT的维持阶段出现过敏反应表明复发的风险较高,持续治疗的耐受性较低.
这些发现为儿童过敏反应事件后BVIT管理的临床决策提供了信息.

关键词:

过敏是一种过敏.过敏反应是一种过敏反应.蜜蜂刺是一种刺.蜜蜂的毒,就是蜜蜂的毒.孩子们的孩子们的孩子们的孩子们.免疫疗法免疫疗法

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