HFD通过改变肠道状态和肠道微生物群来加剧关节炎和动脉样硬化
Na Shi1,2, Shan Jiang1,2, Yue Zhao1,2
1Key Laboratory of Viral Pathogenesis and Infection Prevention and Control (Jinan University), Ministry of Education, School of Medicine, Jinan University, Guangzhou, 510632, China.
Molecular medicine (Cambridge, Mass.)
|December 23, 2024
概括
高脂肪饮食通过破坏肠道微生物群和免疫平衡,使小鼠的类风湿性关节炎 (RA) 和动脉样硬化恶化. 这项研究强调了饮食,肠道健康和慢性炎症疾病之间的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管科学 心血管科学
- 微生物学 微生物学
背景情况:
- 类风湿性关节炎 (RA) 和心血管疾病 (CVD) 是慢性炎症性疾病.
- 在RA中全身炎症和动脉样硬化发展之间的相互作用尚未完全理解.
研究的目的:
- 为了研究高脂肪饮食 (HFD) 对关节炎小鼠模型中动脉样硬化发展的影响.
- 探索HFD对肠道微生物群,肠道平衡和免疫细胞概况的影响.
主要方法:
- ApoE-/-小鼠接受了K/BxN血清和高脂肪饮食 (HFD) 的治疗.
- 表型评估包括高脂血症,动脉样硬化病变和关节病变.
- 分析了免疫特征,重点关注肠道微生物群,肠道屏障功能和免疫细胞群 (Th17/Treg平衡,皮耶斑块,大动脉白细胞).
主要成果:
- 在小鼠中,HFD加剧了超脂血症,动脉样硬化病变和关节炎症状.
- HFD显著改变了肠道微生物群的组成,损害了肠道平衡,并改变了Th17/Treg细胞平衡.
- 观察到皮耶尔斑块减少,肠道免疫细胞表达改变,大动脉白细胞/巨细胞增加,表明炎症加剧.
结论:
- 高脂肪饮食在ApoE-/-小鼠中加剧了关节炎和动脉样硬化.
- 饮食引起的微生物群,肠道透性和免疫平衡的破坏,有助于疾病的严重程度.
- 研究结果表明,饮食,肠道失调和RA和CVD等炎症性疾病的恶化之间存在机械联系.
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