肠道微生物群在扩散大B细胞淋巴瘤免疫化疗期间感染并发症中的作用
Man Sun1, Duozhuang Tang2,3, Jie Jia1
1Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, 1 Min-De Road, Nanchang, Jiangxi, 330006, China.
BMC cancer
|December 23, 2024
概括
在扩散性大B细胞淋巴瘤 (DLBCL) 患者的高基线Enterobacteriaceae预测了免疫化疗期间感染风险. 肠道微生物群的变化为DLBCL中的细菌感染提供了预测价值.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 感染是接受免疫化疗的扩散性大B细胞淋巴瘤 (DLBCL) 患者死亡的主要原因.
- 肠道微生物群在预测DLBCL感染性并发症中的作用尚不清楚.
研究的目的:
- 研究DLBCL患者肠道微生物群组成和细菌感染之间的关系.
- 评估肠道微生物群签名在免疫化疗期间感染并发症的预测能力.
主要方法:
- 来自41名DLBCL患者的便样本的16S rRNA基因测序.
- 在基线,免疫化疗周期期间和之后以及感染/康复期间采样.
- 对肠道微生物群多样性和物种组成的分析,重点是肠道细菌.
主要成果:
- 在DLBCL患者的免疫化学疗法期间,肠道细菌的丰度有动态变化.
- 较高的基线Enterobacteriaceae水平与随后的细菌感染有显著的相关性 (P < 0.0001).
- 基线Enterobacteriaceae丰度>4.5%独立预测的免疫化疗后的细菌感染.
结论:
- 在DLBCL患者中,肠道微生物群的特征在患有感染的患者和没有感染的患者之间有所不同.
- 基线Enterobacteriaceae水平作为预测细菌感染风险的潜在生物标志物.
- 监测肠道微生物群的变化可以帮助免疫化疗后感染的风险分层.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
98
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
98
The Tumor Microenvironment
6.4K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.4K
Inflammatory Bowel Disease IV: Pharmacological Management
79
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
79
Bacterial Flora of the Large Intestine
356
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
356
Tumor Immunotherapy
397
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
397
Cytotoxic T Cells-mediated Immune Response
720
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
720


