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通过支气管囊活检检查COVID-19相关的扩散性副支气管肺异常

Janina Kleymann^1,2, Sascha Brückmann³, Simona Langner^4,5

¹Medical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Janina.kleymann@uniklinikum-dresden.de.

BMC pulmonary medicine

|December 23, 2024

概括

透支支气管切片活检 (TBFB) 有助于在COVID-19后诊断持续的肺部异常,特别是在免疫受损患者中组织肺炎 (OP). 这种方法显示了OP的高频率和类固醇治疗的良好结果.

科学领域:

肺部病理学肺部病理学
传染性疾病传染性疾病
放射学放射学是一门学科.

背景情况:

在COVID-19后持续的肺部异常需要进一步的诊断评估.
肺活检在这些情况下的实用性,特别是在组织肺炎 (OP) 方面,尚未得到充分证实.
免疫功能低下 (IC) 患者在COVID-19后肺部疾病管理中存在独特的挑战.

研究的目的:

为了评估跨支气管切片活检 (TBFB) 对SARS-CoV-2感染后持续的肺异常的诊断价值.
具体评估TBFB在确定组织性肺炎 (OP) 模式中的作用.
分析COVID-19后肺部异常的免疫功能低下 (IC) 患者的TBFB实用性.

主要方法:

对COVID-19后扩散性肺部变化进行的TBFB程序的描述性回顾性分析.
数据从2020年3月到2023年6月在一个单一中心收集.
专注于患有SARS-CoV-2感染后持续胸部CT异常的患者.

主要成果:

分析了27个TBFB手术,其中23个是IC患者.
在44% (12/27) 的样本中观察到组织性肺炎 (OP) 的高频率.
89%的患者在出院时出现了良好的临床结果,其中包括92%的OP患者,通常使用类固醇治疗.

结论:

TBFB对于在COVID-19之后诊断扩散性肺异常非常有价值,经常识别OP,特别是在IC患者中.
这些发现表明,TBFB在这个队列中对患者管理做出了重大贡献.
需要进一步的大规模研究来证实这些结果并优化类固醇治疗策略.

关键词:

与COVID-19相关的肺部变化免疫力受损的人.组织肺炎的组织通过支气管的活检.

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