调节器的调节:长非编码RNA作为慢性疾病管理中的自控制器
Aviral Kumar1, Kenneth Chun-Hong Yap2,3, Bandari BharathwajChetty1
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India.
Journal of biomedical science
|December 24, 2024
概括
长非编码RNAs (lncRNAs) 调节自,这是一个细胞过程,对恒温至关重要. 功能失调的自与疾病有关, lncRNAs 具有作为诊断生物标志物和治疗点的潜力.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 遗传学 遗传学 是一个
背景情况:
- 慢性疾病需要了解新疗法的潜在机制.
- 自通过降解受损组件来维持细胞平衡;其破坏与癌症和神经系统疾病等疾病有关.
- 长非编码RNAs (lncRNAs) 是基因表达和细胞过程的关键调节者.
研究的目的:
- 在各种病理性疾病中审查自功能障碍中lncRNAs的多层调节.
- 突出最近关于lncRNA自细胞调节的发现及其临床潜力.
- 探索 lncRNAs作为生物标志物和自相关疾病的治疗点.
主要方法:
- 文献综述侧重于lncRNAs,自和疾病机制.
- 分析 lncRNA 在转录和转录后基因调节中的作用.
- 检查lncRNAs作为竞争的内源RNAs (ceRNAs) 测序微RNAs.
主要成果:
- lncRNAs调节各种生理过程,包括增殖,发育,免疫和新陈代谢.
- lncRNAs通过隔离microRNAs和影响与自相关的基因 (ATG) 来调节自.
- 失调的lncRNAs与各种疾病的发病有关,包括癌症和神经系统疾病.
结论:
- lncRNAs在调节自中起着至关重要的作用,并与疾病的发病有关.
- lncRNAs显示出作为自相关疾病的诊断生物标志物和治疗点的巨大潜力.
- 针对 lncRNAs 可能为个性化医学和复杂疾病的治疗提供新的途径.
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