肝脏遗传性视觉神经病变患者的视觉功能
Robin Francomme1, Quentin Lenoble, Vasily Smirnov
1Exploration de la Vision et Neuro-Ophtalmologie (RF, VS), CHU de Lille, Lille, France; and University of Lille (QL, VS, MB), INSERM, CNRS, UMR-S 1172-Lab, Lille Neuroscience & Cognition, Lille, France.
概括
勒伯遗传性视神经病 (LHON) 严重损害了面部表情识别. 虽然对象操纵速度较慢,但患有LHON的人可以有效地使用外周视力进行有目的的行动.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 视觉科学 视觉科学
背景情况:
- 传统的勒伯遗传性视神经病 (LHON) 视觉功能数据依赖于患者的自我报告.
- 本研究通过基于性能的测试客观地评估了LHON对视觉处理的影响.
研究的目的:
- 评估LHON患者面部识别和有目的的行动执行方面的具体缺陷.
- 为了比较LHON患者和年龄相匹配的对照人群之间的视觉任务性能.
主要方法:
- 十二名LHON患者中枢瘤 (5°-20°) 和12名对照进行了面部识别 (性别/表情) 和对象操纵任务.
- 面部识别包括查看越来越大的图像;对象操纵包括记录与真实对象互动时的眼睛运动.
主要成果:
- LHON患者表现出面部表情识别受损,尽管在1米的模拟距离上,性别识别是可能的.
- 与对照组相比,LHON患者的任务执行速度较慢.
- 患者表现出动态的视觉采样策略,由更长的扫描路径和增加的跳动/固定证明.
结论:
- 面部感知,特别是表情识别,在LHON中显著受到损害.
- 尽管性能减慢,LHON患者可以有效地利用外周视力进行有目的的对象操纵.
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