在极度早产的婴儿中,无法解释的肠道症状与5.5岁的胃肠功能障碍有关
Júlíus Kristjánsson1,2, Karin Sävman1,2, Kerstin Allvin1,2
1Department of Paediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
在新生儿期出现显著胃肠道 (GI) 症状的极度早产婴儿面临更高的长期胃肠道功能障碍的风险. 这种增加的概率甚至在没有重大腹部手术或死性肠球炎的情况下仍然存在.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 围产儿医学 围产儿医学
背景情况:
- 极度早产的婴儿通常会出现胃肠道 (GI) 并发症.
- 这种人群中新生儿胃肠道症状的长期影响需要进一步研究.
- 识别晚期胃肠道功能障碍的危险因素对于改善婴儿结果至关重要.
研究的目的:
- 为了确定极度早产婴儿中相当大的新生儿胃肠道症状是否预测了以后的胃肠道功能障碍.
- 评估这种关联是否独立于重大腹部手术或死性肠球炎.
- 评估二次结果,包括呼吸,神经和生长异常.
主要方法:
- 采用了追溯病例控制研究设计.
- 极度早产的新生儿 (平均妊娠年龄25w 4d) 与上部GI对比系列 (UGI) 被确定为病例.
- 病例与性别和妊娠年龄的对照进行了匹配,以5.5岁的胃肠道功能障碍为主要结局.
主要成果:
- 患有新生儿胃肠道症状的婴儿在5.5岁时患上胃肠道功能障碍的几率比率 (3.8) 显著增加.
- 与新生儿相关的发病情况,如败血症和动脉管 (patent ductus arteriosus),在这些病例中更为频繁.
- 在5.5年后的呼吸,神经或生长结果中没有发现显著差异.
结论:
- 在极度早产的婴儿中,新生儿无法解释的胃肠道症状与以后患上胃肠道功能障碍的可能性更高有关.
- 这种关联不能归因于其他常见的新生儿疾病.
- 对于具有新生儿胃肠道症状的极度早产婴儿,建议对长期胃肠道问题的临床警.
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