RNA结合蛋白HuR通过调节CD147来调节败血性AKI到CKD的过渡

Simeng Liu1,2, Renfei Luo1, Davey Li1

  • 1Division of Nephrology & Hypertension, Department of Internal Medicine, University of Utah Health Science, Salt Lake City, UT, USA.

概括

升高的Hu抗原R (HuR) 会通过增加炎症和纤维化,导致性急性损伤 (AKI) 进展为慢性病 (CKD). 用KH39或尼古洛萨米德抑制HuR显示出逆转损伤的治疗潜力.

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