Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

899
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
899
Development of Immunocompetence01:22

Development of Immunocompetence

283
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
283
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.4K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.4K
Vaccinations01:51

Vaccinations

44.1K
Overview
44.1K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

745
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
745

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS).

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.

Blood advances·2025
Same author

Inborn Errors of Immunity in Pediatric Intensive Care: Prevalence, Characteristics, and Prognosis.

Pediatrics·2025
Same author

Guiding Drug Provocation Testing for Ibuprofen Hypersensitivity in a Pediatric Population: Development of the I3A Risk-Stratification Tool.

Pediatrics·2025
Same author

Genetic Testing in Patients With Autoimmune Lymphoproliferative Syndrome: Experience of 802 Patients at Cincinnati Children's Hospital Medical Center.

Pediatrics·2025
Same author

Prevalence of Ophthalmological Manifestations in Patients With Inborn Errors of Immunity: A Systematic Review and Meta-Analysis.

Pediatrics·2025
Same journal

Overlapping Mechanisms and Novel Biomarkers Define Asthma and COPD as a Spectrum of Airway Disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Real-World Variation in Post-Dose Supervision and Activity Restriction During Maintenance Cow's Milk Oral Immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Small Airway Dysfunction and Prior Exacerbations are Common in Primarily Well-Controlled Pediatric Asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Elevated Absolute Eosinophil Counts are Associated with Hypertension, Coronary Heart Disease, and Stroke.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Biomarkers for COPD with Type 2 Inflammation.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
查看所有相关文章

相关实验视频

Updated: Jun 4, 2025

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

8.9K

随时跟上免疫缺陷的最新发展.

Michael W Tsoulis1, Kelli W Williams2

  • 1Section of Allergy and Clinical Immunology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
|December 24, 2024
PubMed
概括
此摘要是机器生成的。

免疫的先天性错误 (IEI) 是一种遗传性免疫系统疾病. 最近的进展已经确定了超过485个IEI,有助于诊断和治疗策略.

更多相关视频

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.5K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.7K

相关实验视频

Last Updated: Jun 4, 2025

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

8.9K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.5K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.7K

科学领域:

  • 免疫学 免疫学 免疫学
  • 遗传学 是一个遗传学.
  • 临床医学 临床医学

背景情况:

  • 免疫的先天性错误 (IEI) 代表了一个日益增长的单遗传免疫系统疾病类别.
  • 最近在基因测试和功能研究方面的突破显著加速了IEI基因和疾病机制的发现.
  • 国际免疫学会联盟 (IUIS) 更新了IEI分类,最新的分类是在2022年,现在涵盖了10个主要组的485多种疾病.

研究的目的:

  • 审查IEI领域最近的临床进展.
  • 为了深入研究新发现的IEI疾病.
  • 提供关于IEI的诊断,管理和治疗的指导.

主要方法:

  • 对IEI近期临床发展的文献综述.
  • 对2022年IUIS IEI分类的分析.
  • 突出特定的IEI疾病的表型,包括严重的亚托皮,免疫失调,淋巴增殖,自身炎症和先天免疫缺陷.

主要成果:

  • 描述的IEI的数量已经超过485个,分为10个主要组.
  • 最近的发现扩大了对IEI遗传学和疾病机制的理解.
  • 越来越多地认识到特定的IEI表型,如严重的亚托皮,免疫失调和自身炎症.

结论:

  • 临床医生可以利用可疑IEI的最新诊断方法.
  • 对IEI的管理和治疗策略正在随着新的发现而发展.
  • 持续的研究和分类更新对于解决IEI不断扩大的局面至关重要.