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来自人类临床样本的Beta-lactamase基因在Enterobacteriaceae中的分布

Md Kaisar Rahman¹, Babafela Awosile¹

¹Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA.

Infectious diseases now

|December 24, 2024

概括

贝塔-乳酸酶基因在人类样本中的肠杆菌群中广泛存在,其中包括Klebsiella spp. 和大肠杆菌显示的最高患病率. 持续监测对于了解One Health接口中的抗菌素耐药性至关重要.

科学领域:

微生物学微生物学
遗传学是一个遗传学.
流行病学流行病学

背景情况:

肠杆菌群是人类感染的重要来源.
贝塔-乳酸酶基因赋予了对关键抗生素的耐药性.
了解这些基因的分布对于公共健康至关重要.

研究的目的:

从人类临床样本中调查Enterobacteriaceae中β-lactamase基因的全球分布.
为了识别流行的β-乳糖酶基因及其相关的细菌物种.
为了告知抗微生物耐药性监测策略.

主要方法:

通过"抗微生物测试领导和监督计划"分析来自83个国家的数据 (2004-2021年).
在九种细菌物种中计算β-乳酸酶基因比例.
在至少一个物种中生成频率≥1%的基因热图.

主要成果:

359个β-乳糖酶基因被确定.
克莱布西埃拉 spp. 的种类. 大肠杆菌 (61.84%) 和大肠杆菌 (47.63%) 的基因比例最高.
在Klebsiella spp.中 blaCTX-M-15 (ESBL) 是最常见的. 和大肠杆菌;NDM-1,OXA-48和KPC-2 (carbapenemases) 在Providencia spp.,Raoultella spp.和Serratia spp.中较高.

结论:

在Enterobacteriaceae中观察到β-乳糖酶基因的显著多样性和流行率.
像blaCTX-M-15,blaNDM-1,blaOXA-48和blaKPC-2这样的特定基因是抵抗性的关键决定因素.
需要进一步的研究来了解这些基因跨越One Health接口.

关键词:

贝塔-乳酸酶基因的基因分发方式分发方式分发方式它们的属性是 Enterobacteriaceae.blaCTX-M−1515 的时间.这就是blaNDM-1的原因.

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