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相关概念视频

Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Ovarian Cycle01:27

Ovarian Cycle

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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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Hormonal Control of the Ovarian Cycle01:30

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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
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Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification
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动物雌性循环模式:协调循环评估和解释.

Shivakumar Holalagoudar1, Susan Kisielewski1, Austin Martini1

  • 1Corteva Agriscience, Haskell R&D Center, 1090 Elkton Road, Newark, DE, 19711, USA.

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PubMed
概括
此摘要是机器生成的。

动物生殖毒性研究中的期周期时间可能会有所不同,特别是在延长的期阶段. 协调方法对于准确的内分泌干扰剂评估至关重要.

关键词:
周期长度 周期长度气周期的气周期是什么经合组织指导方针 经合组织指导方针动物 动物

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科学领域:

  • 生殖毒理学 生殖毒理学
  • 内分泌学 在内分泌学.
  • 动物模型动物模型

背景情况:

  • 雌性循环是生殖毒性研究的关键指标,特别是在评估内分泌干扰剂时.
  • 目前用于性周期计时的方法显示测试实验室之间存在差异.

研究的目的:

  • 审查动物生殖毒性研究中的雌性周期计时和评估方法.
  • 识别和解决雌性周期计数中的不一致性,特别是关于延长雌性阶段的不一致性.

主要方法:

  • 审查现有的文献和测试实验室协议,以评估雌性周期.
  • 分析周期计数中的差异,重点关注延长性雌激 (E) 和前雌激 (P) 阶段.

主要成果:

  • 在计算标准的4天雌性周期时,没有发现显著差异.
  • 当延长性雌性期发生时,会出现差异,这可能导致对结果的误解.
  • 目前的经合组织指导可能对涉及延长性期的5天周期不清楚.

结论:

  • 需要对雌性周期计数进行标准化,特别是对于具有延长雌性周期的4/5天周期.
  • 建议包括更新经合组织的指导和定义异常循环模式 (例如,P后有两个E,连续三个E).
  • 鼓励合作,协调性循环计数方法,以进行可靠的毒性评估.