基于氧化的功能化自我辅助纳米疫苗通过Dectin-1信号传递协调抗瘤免疫反应

Xiaoli Ling1, Zhipeng Tian1, Dong Chen1

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Centre for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China.

概括

一种结合和β-1,3-葡萄糖的新型自我辅助纳米疫苗显示出强大的抗瘤免疫力. 该平台增强了抗原递送和免疫细胞激活,在临床前模型中显著提高了生存率.