慢性肝炎三角洲型肝炎患者中COVID-19感染的过程
Yavuz Emre Parlar1, Müge Özarı Gülnar2, Beril Kırmızıgül3
1Department of Gastroenterology, Hacettepe University Medical School, Ankara, Turkey.
Journal of viral hepatitis
|December 24, 2024
概括
慢性肝炎三角形 (CHD) 患者的COVID-19结果比慢性肝炎B (CHB) 患者更严重. 这可能是由于肝硬化率较高和缺乏有效的肝炎D病毒 (HDV) 治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 高龄和并发症增加了COVID-19死亡风险.
- 酒精性肝病与COVID-19患者的死亡率有关.
- COVID-19对慢性肝炎三角形 (CHD) 的影响仍未得到充分研究.
研究的目的:
- 在患有慢性乙型肝炎 (CHB) 和CHD的患者中调查2019年冠状病毒病 (COVID-19) 的病程.
- 为了比较CHB和CHD患者队列之间的COVID-19结果.
主要方法:
- 对来自哈塞特佩和科奇大学医院的CHB和CHD患者的回顾性研究.
- 通过SARS-CoV-2 RNA PCR测试确认了COVID-19. 这是一个非常好的方法.
- 收集的数据包括肝病严重程度 (MELD-Na,Child-Pugh分数) 和疫苗接种情况.
主要成果:
- 评估了618名患者:540名CHB (5%的肝硬化) 和78名CHD (55%的肝硬化).
- 在8.7%的CHB和15.4%的CHD患者中诊断出COVID-19 (p=NS).
- 在6.3%的CHB和33%的CHD患者 (p=0.018) 中发生了肝脏重新激活,在肝硬化患者中更频繁 (50%对4%,p=0.0009).
- 一名CHB患者失补偿; 一名CHD患者死亡,另一个失补偿.
- 大多数肝性CHB患者接受了核类相似物 (NA);只有一个肝性CHD患者接受了肝炎D病毒 (HDV) 治疗.
结论:
- 与慢性乙型肝炎 (CHB) 患者相比,慢性乙型肝炎 (CHD) 患者可能面临更严重的COVID-19过程.
- 冠状动脉疾病患者中肝硬化率较高,缺乏有效的HDV抗病毒疗法可能导致结果更差.
- 由于COVID-19的CHD患者的样本规模很小,因此需要进行进一步的研究.
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