肝草Radula marginata中独特的双化大麻素:与大麻化学相似
Christelle M Andre1, Catherine E Sansom2, Blue J Plunkett1
1The New Zealand Institute for Plant and Food Research Limited (PFR), Mt Albert Research Centre, Auckland, 1142, New Zealand.
The New phytologist
|December 24, 2024
概括
新西兰肝草 (Radula marginata) 产生的氨酸 (PET) 是一种类似于THC的大麻素. 这项研究在R. marginata中发现了新的大麻素和化学型,表明了大麻素生物合成的遗传控制和融合进化.
科学领域:
- 植物化学 植物化学
- 民族植物学 民族植物学
- 进化生物学 进化生物学
背景情况:
- 大麻素越来越多地被用于公共卫生应用,推动了除大麻以外的替代植物来源的研究.
- 新西兰特有肝的Radula marginata产生百丁烯 (PET),这是一个结构上类似于四大麻素 (THC) 的双基大麻素.
- 与大麻衍生化合物相比,研究R. marginata为新型大麻素疗法提供了潜在的潜力,与大麻衍生化合物相比,可能会改变副作用概况.
研究的目的:
- 为了研究Radula marginata的大麻素生产潜力.
- 描述新型大麻素,并了解R. marginata的代谢可塑性.
- 评估R. marginata.中的大麻素化学型的遗传基础.
主要方法:
- 分析了来自不同地点和季节的75个R. marginata收藏.
- 在受控条件下和体外培养下评估代谢可塑性和植物生长.
- 隔离和表征双化大麻素及其前体.
主要成果:
- 二醇 (PTD) 和其前体PTDA的识别和特征,类似于大麻 (CBD) 和其酸.
- 隔离双-4-基拉尼 (BB4G) 和其酸BB4GA,类似于大麻基拉尼 (CBG).
- 发现了由PET,PTD或BB4G主导的独特的R. marginata化学型,这些化学型在体外和人工照明下稳定,表明了遗传控制.
结论:
- 拉杜拉 (Radula marginata) 代表了新型大麻素的重要来源,扩大了已知的植物大麻素多样性.
- 鉴定到的化学类型表明R. marginata中的大麻素生产具有遗传基础,类似于Cannabis.
- 这些发现支持了肝和大麻之间大麻素生物合成的融合进化假设.
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