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Updated: Jun 20, 2026

Depletion and Reconstitution of Macrophages in Mice
08:50

Depletion and Reconstitution of Macrophages in Mice

Published on: August 1, 2012

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抑制BRD4将心脏巨细胞重新连接到一个具有低MHCII类表达率的保护性表型

Katherine B Schuetze1,2, Matthew S Stratton1,2, Rushita A Bagchi1,2

  • 1Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.

American journal of physiology. Heart and circulatory physiology
|December 24, 2024
PubMed
概括

使用JQ1进行基因和外端域 (BET) 抑制,减少了亲炎性单细胞的招募,并重新编程心脏巨细胞. 这种表观遗传方法限制了心脏病发作的扩张,并促进了心脏损伤后的愈合.

关键词:
这就是BRD4D.这是心脏病,心脏病.巨细胞是一个巨细胞.

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