诱导合等离子体质谱性能测量关键血清矿物质:与标准量化方法进行比较研究
Kosuke Kojo1,2, Tomoko Oguri3, Takazo Tanaka1
1Department of Urology, Institute of Medicine University of Tsukuba, Tsukuba, Japan.
Journal of clinical laboratory analysis
|December 24, 2024
概括
感应合等离子体质谱法 (ICP-MS) 准确测量血清必需矿物质,对大多数元素与标准方法有很好的一致性. 测量需要进一步调查,因为存在显著的差异.
科学领域:
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断
- 微量元素分析 微量元素分析
背景情况:
- 感应合等离子体质谱法 (ICP-MS) 是矿物分析的强大工具.
- 它对血清必需矿物质量定量的实用性需要彻底评估.
- 这项研究解决了在临床环境中评估ICP-MS性能的需要.
研究的目的:
- 评估ICP-MS测量八个关键血清矿物质的性能.
- 为了比较ICP-MS的结果与既定的标准量化方法.
- 识别潜在的挑战,并为临床应用提供见解.
主要方法:
- 一项涉及282名来自日本的参与者的横截面研究.
- 使用ICP-MS和标准方法测量了,,,,,,铁,和铜的血清度.
- 数据分析使用了Passing-Bablok回归和Bland-Altman图表来评估协议.
主要成果:
- ICP-MS与,,,,,,和铜的标准方法有很好的一致性.
- 过异常值后,平均相对误差处于可接受范围之内,但铜 (-19%) 除外.
- 对于,观察到显著的差异,ICP-MS产生的值大约是标准无机测量的3.5倍.
结论:
- ICP-MS是一种可行的血清必需矿物质分析方法,对大多数元素具有良好的协议.
- 异常值分析揭示了影响铁 (血解) 和测量的特定因素.
- 需要进一步的研究,以使用血清中的ICP-MS精确量化.
相关概念视频
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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle
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Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
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